It took just two minutes of the second half for Ziyech to score after a scoreless first half, sending a beautiful shot into the top corner from 20 yards following a brilliant run by Callum Hudson-Odoi.
Eight minutes later, the hosts increased their advantage when defender Thiago Silva headed home Mason Mount’s brilliant free-kick ball.
Tottenham believed they had grabbed the lead in the first half when Harry Kane tapped past Kepa Arrizabalaga, but the goal was disallowed when it was determined that the England striker had shoved Silva to the ground.
Earlier in the season, Chelsea cruised to a 3-0 aggregate victory over Tottenham in the Carabao Cup semi-finals, setting up a meeting with Liverpool in the final at Wembley Stadium.
In November, Tottenham’s first league loss has come since Antonio Conte took over for the ousted Nuno Espirito Santo. Conte, who won the Premier League and FA Cup when in charge of Chelsea, was appointed as a replacement for Espirito Santo.
While Conte was dissatisfied with the referees’ decision to rule out Tottenham’s first-half goal, Tuchel was enraged when Japhet Tanganga, who had previously been booked, was not awarded a second yellow card he grabbed Hudson-shirt Odoi’s late in the first half.
Following Matt Doherty’s earlier catch of Malang Sarr by stepping on his ankle – which was ruled an accident by a video assistance referee – Chelsea felt they should have had a player sent off for the second time in as many games.
However, Tottenham, who would have gone into the top four with a victory, had their resistance overcome early in the second half by Ziyech’s miracle shot, before Silva’s goal put the game beyond them.
Due to the missed opportunities by Lukaku, Mount, and Cesar Azpilicueta, Chelsea may have won by a more significant margin.